원광대 분자면역학 면역관용과 mtor ppt발표자료
- 최초 등록일
- 2018.06.04
- 최종 저작일
- 2017.08
- 26페이지/
MS 파워포인트
- 가격 2,000원
목차
1. Immunological tolerance
2. Regulatory T cell(Treg)
3. Foxp3의 발현
4. mTOR
5. Foxp3와 Treg
6. 최근 연구동향
본문내용
면역관용
Immunological tolerance
Central tolerance
림프구 전구세포→ 미성숙 림프구-자가항원 인식
→조절 T 림프구의 발달 (CD4⁺ T 세포만)
→수용체의 변화(수용체 편집; B세포)
→세포자멸사 (결실)
Peripheral tolerance
성숙림프구
자가항원 인식
→ 억제
→ 세포자멸사(결실)
→ 무반응
Immunological tolerance
특정 조건에서 항원과 접촉한 동물이 동일 항원에 반응하지 않고 내성을 갖는다는 말(정상적인 개체는 자가항원에 대해 관용을 가진다.)
참고 자료
http://m.bdbiosciences.com/kr/research/tcell/regulatorytcells/workflow/index.jsp
http://tcell.snu.ac.kr/Regulatorytcell
https://www.thermofisher.com/kr/ko/home/life-science/cell-analysis/cell-analysis-learning-center/cell-analysis-resource-library/ebioscience-resources/t-regulatory-cells-overview.html#/legacy=ebioscience.com
https://www.slideshare.net/AllergyChula/immunological-tolerance-70056314?qid=d2b4ab96-50de-461a-af6a-34b5a9009879&v=&b=&from_search=2
http://m.cafe.naver.com/idoctorplus/387
https://www.cellsignal.com/contents/science-pathway-research-pi3k-akt-signaling-resources/mtor-signaling-pathway/pathways-mtor-signaling
최신면역학(미생물, 면역분과학회) 라이프사이언스 p..231-249
Cellular and Molecular Immunology 8th edition ELSEVIER p.-359-386
Regulation and function of mTOR signalling in T cell fate decision
Hongbo Chi Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA, Published in final edited form as: Nat Rev Immunol . ; 12(5): 325–338. doi:10.1038/nri3198
Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011; 12:21–35. [PubMed: 21157483]
Thomson AW, Turnquist HR, Raimondi G. Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol. 2009; 9:324–337. [PubMed: 19390566] 3. Araki K, Ellebedy AH, Ahmed R. TOR in the immune system. Curr Opin Cell Biol. 2011
Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010; 327:291–295. [PubMed: 20075244] 6. Delgoffe GM, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009; 30:832–844. Provides the first genetic evidence for mTOR in promoting CD4+ effector T cell differentiation while inhibiting induction of TReg cells. [PubMed: 19538929]
