보톡스(Neurotoxin)

소개글

보톡스에 관한 내용입니다. (앞에만 영어 뒤에는 한글)

Clostridium botulinum의 독소에 의한
신경전달 저해 Mechanism과 응용분야

를 소주제로 하여 파워포인트 작성했습니다.

작용기작과 지금 사용하고 있는 곳, 그리고 추후 사용되어져야 할 것등

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목 차
What is Botulism
- Clostridium botulinum
- 감염기작 & 경로
- 증상

Botulism의 응용
- 성형
- 통증, 질병 치료

What is Botulism?
Characteristics
Characteristics ? The Toxin
Structure
Normal Neurotransmitter Release
Symptoms
Treatment & prevention
How to use?
의료 분야
- 성형
- 질병, 통증 치료
전립선 비대증 치료
후두암 수술 후 부작용 치료
비루관 폐쇄증 치료
향후 전망

목차

What is Botulism
- Clostridium botulinum
- 감염기작 경로
- 증상
Botulism의 응용
- 성형
- 통증, 질병 치료

본문내용

What is Botulism?
Serious paralytic illness, caused by a nerve
toxin that is produced by the bacterium
Clostridium botulinum.
Three main kinds of botulism.
- borne botulism.
- Wound botulism.
- Infant botulism.
Characteristics
A gram positive,
obligate anaerobic,
spore-forming,
rod-shaped bacterium.
Commonly found in soils
and marine sediments.
Since it is found in the soil,
it may contaminate vegetables cultivated
in or on the soil.
Characteristics The Toxin
The toxin types are classified
as A, B, C1, D, E, F and G.
Human botulism is primarily caused by Clostridium
botulinum that produce toxin type A, B and E.
Type F toxin produced by Clostridium baratii and
type E toxin produced by ium butyricum
have also been implicated in human botulism.
Light Chain
n
Structure
The heavy chain
- 100kDa, binding
translocation activity.
divided functionally
into an amino terminal
domain(Hn) and a carboxyl
terminal domain(Hc).
(1) The carboxyl terminal domain
the binding domain.
tion of the toxin molecules
into cholinergic neurons.
(2) The amino terminal domain
the translocaion domain.
form ion channels in lipid bilayer
Structure The Heavy Chain
Structure The Light Chain
The light chain
- Catalytic domain
- acts as an endopeptidase.
Normal Neurotransmitter Release
시냅스
수상돌기
축색돌기
수상돌기
Normal Neurotransmitter Release
V-SNARE

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