A review of Hydrogel complex/수화물 복합체의 리뷰

소개글

"A review of Hydrogel complex/수화물 복합체의 리뷰"에 대한 내용입니다.

목차

1. Introduction

2. Macrogel
2-1 Cesium adsorbent
2-2 Microfluidic device
2-2-1 Pump strategy
2-2-2 Sensor
2-3 Therapy
2-3-1 Photothermal therapy
2-3-2 Chemotherapy
2-3-3 Multitherapy
2-3-3-1 Photothermal therapy + starvation therapy
2-3-3-2 Photothermal therapy + chemotherapy
2-4 Acutator
2-5 Microdevices
2-5-1 Microvalve

3. Microgel
3-1 PNIPAAm-Prussian blue
3-2 PNIPAAm-iron oxide
3-3 PNIPAAm-gold
3-4 PNIPAAm-carbon sphere
3-5 PNIPAAm-polydopamine
3-6 PNIPAAm-ZnO
3-7 PNIPAAm-silver

4. Nanogel
4-1 Photothermal responsive
4-2 Magnetic responsive
4-3 Thermal responsive
4-4 pH responsive
4-5 Dual responsive
4-5-1 Thermal & pH responsive
4-5-2 Thermal & ion responsive

5. Non-hydrogel-Prussian blue

6. Prussian blue
6-1 polymer modified Prussian blue
6-2 Hollow Prussian blue
6-3 Core-shell
6-3-1 Prussian blue core-Fe3O4 shell
6-3-2 Fe¬3O4 core-Prussian blue shell

7. Reference

본문내용

하이드로젤 (hydrogel)은 높은 친수성을 갖지만 물에는 불용성인 3차원 고분자 네트워크의 한 종류로서 고분자 사슬이 물리적 또는 화학적인 가교로 인해서 합성할 수 있습니다. 또한 크기별로 nanogel (20-200 nm), microgel (300-1000 nm), macrogel (20-200 um)로 구분지을 수 있습니다. [1] 이러한 하이드로젤중에서 외부 자극 (온도, pH, 빛, 자기장, 전기장)에 의해서 졸-젤 전이 (sol-gel transition)를 조절할 수 있습니다. 그 중에서도 poly(N-isoproplyacrlyamide) (PNIPAAm)은 가장 많이 연구된 온도 감응 하이드로젤로서, 32~35 ℃에서 젤화가 일어나고 식으면 다시 졸상태로 열 가역적인 젤화 특성을 가지고 있습니다. 이러한 친수성/소수성 상태의 가역성은 LCST (low critical solution temperature) 이하 또는 이상 온도를 변화시킴으로써 발생합니다.
PNIPAAm은 아래 그림과 같이 극성기인 C=O, N-H와 비극성기인 iso-proyl 기, 고분자 backbone을 가지고 있다. Cloud point를 기준으로 낮을 때는 수화된 상태로 hydrophilic state라고 불리고, 높을 때는 탈수화된 상태로 collapsed state라고 불린다. 온도가 낮을 때는 극성기가 물과 잘 상호작용을 하기 때문에 잘 녹거나 팽창되어 있는 상태이지만, 온도가 높을 때는 비극성기끼리 상호작용하는 힘이 더 크기 때문에 수축되어 불용성을 갖게 됩니다. 따라서 온도에 따라서 가역적으로 팽창과 수축을 할 수 있습니다.[2]

PNIPAAm의 LCST는 인간의 체온 (약 36.5~37.5 ℃)에 가깝고, 생체적합성을 가지고 있기 때문에 특히, PNIPAAm에 대한 많은 연구가 진행되고 있습니다. PNPAAm 하이드로젤은 라디칼 중합을 통해 중합할 수 있으며 다른 monomer와 함께 중합되어 블록 공중합체를 이룰 수 있고, 가교를 시켜 젤로도 중합할 수 있습니다. [2,3]

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