Retrospective study of 23 dogs with meningoencephalomyelitis of unknown etiology
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서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical and Translational Research / 23권 / 4호
ㆍ저자명 : Jun-Hee Kim, Yoonhoi Koo, Taesik Yun, Yeon Chae, Dohee Lee, Sijin Cha, Jeeyun Kim, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
ㆍ저자명 : Jun-Hee Kim, Yoonhoi Koo, Taesik Yun, Yeon Chae, Dohee Lee, Sijin Cha, Jeeyun Kim, Hakhyun Kim, Mhan-Pyo Yang, Byeong-Teck Kang
목차
AbstractINTRODUCTION
MATERIALS AND METHODS
Case selection
Group assignment according to survival time
Prognostic factor analysis
Treatment
Statistical analysis
RESULTS
Study population
Group analysis according to successful long-term outcome
Group analysis according to treatment
Analysis according to survival time
DISCUSSION
REFERENCES
영어 초록
This study aimed to identify prognostic factors and describe the treatment outcomes of multidrug therapy in dogs with meningoencephalomyelitis of unknown etiology (MUE). A total of 23 dogs diagnosed with MUE were treated with prednisolone in combination with cyclosporine, cytosine arabinoside (CA), leflunomide, and mycophenolate mofetil. Based on the survival time, these dogs were divided into two groups: group A (n = 10), surviving for < 100 days, and group B (n = 13), surviving for > 100 days. Signalment, seizure activity, cerebrospinal fluid (CSF) analysis results, and magnetic resonance (MR) imaging findings were reviewed. Survival studies were conducted to investigate the association of each prognostic factor and treatment with the clinical outcome. There were no significant differences in age, sex, body weight, occurrence of seizures, cell number and protein concentration in the CSF, or location of lesions between groups A and B. Abnormal MR features were more frequently observed in group A than in group B. It was identified that the longest median survival time was administration of multi-drug therapy including CA. In conclusion, abnormal MR features were associated with poor prognosis in dogs with MUE and CA-based multi-drug therapy could be considered the most effective treatment of MUE.참고 자료
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