위염 및 위궤양에 미치는 Propolis 추출물의 영향
(주)코리아스칼라
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- 2023.04.05
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- 1999.12
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서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 14권 / 4호
ㆍ저자명 : 김은주, 정기화, 정춘식
영어 초록
Propolis, a natural resinous compound collected from honey bees, contains many biochemical constituents and has been used in traditional medicines as early as 300 B.C. Recently, it has been reported to possess many biological activities such as antibacterial, antiviral, fungicidal, local anaesthetic, immunostimulating, antiinflammatory and free radical scavenging properties. This study was performed to investigate the pharmacological effects of the propolis extract and fractions on the gastric lesion and ulcer. The ethanol extract was fractionated with hexane, toluene and ethyl acetate. Followed by bioassay on antigastric and antiulcer activity. Propolis ethanol extracts(500, 750, 1,000, 1,500 and 2,000 mg/kg) showed the protective effect on HCl ethanol-induced gastric lesion and the antisecretory effect against Shay's gastric secretion in pylorus-ligated rats in a dose related manner. In the animal models of HCl ethanol, aspirin-induced gastric lesion and Shads gastric secretion, the hexane and toluene fraction of propolis significantly reduced the length of gastric lesion and the acid secretion. These data showed that the gastric protective effects of propolis might result from reduction of acid secretion through the inactivation of H^+/K^+ATPase activity.
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