알로에의 과산화지질 억제효과에 관한 연구

서지정보

ㆍ발행기관 : 한국식품위생안전성학회 ㆍ수록지정보 : 한국식품위생안전성학회지 / 11권 / 2호
ㆍ저자명 : 하배진

영어 초록

The antilipidperoxidative and hepatopreventive effects of Aloe water extract (30 mg, 50 mg, 100 mg) were investigated at the levels of liver-total homogenates and the sera of SDrats intoxicated with CCl₄, (0.5 cc/100 g) and 50% ethanol. We measured MDA (Malondialdehyde) in the liver homogenate, AST (L-Aspartate-2-oxoglutarate aminotransferase) and ALT(L-Alanine-2-oxo-glutarate aminotransferase) in the serum. The analysis of the measurement indicated that Aloe water extract reduced MDA, ALT and AST significantly and their reduction was in relation to dose dependence. In rat liver homogenate intoxicated with ethanol and CCl₄, Aloe treatment group markedly inhibited lipidperoxidation by 30%-70%. In rat serum intoxicated with ethanol and CCl₄, Aloe treatment group inhibited AST, ALT by 40%-90%. In these data Aloe may be used to inhibit or prevent the hepatic toxicity which results from the environmental and alcoholic factors through the further study of its exact antihepatotoxic mechanism.

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