Single-dose acute toxicity of intraperitoneally administered Vital-Shoot containing reduced glutathione in ICR mice
(주)코리아스칼라
- 최초 등록일
- 2023.04.05
- 최종 저작일
- 2017.09
- 4페이지/ 어도비 PDF
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서지정보
ㆍ발행기관 : 한국예방수의학회(구 한국수의공중보건학회)
ㆍ수록지정보 : 예방수의학회지 / 41권 / 3호
ㆍ저자명 : Chun-Nam Cha, Eun-Kee Park, Chang-Yeul Yoo, Suk Kim, Hu-Jang Lee
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영어 초록
This study examined the acute toxicity of Vital-Shoot containing reduced glutathione in male and female ICR mice. Mice were intraperitoneally injected the drug at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for single-dose toxicity test. There were no statistical differences in BW changes between the control and all treated groups. Based on hematological and blood biochemical analyses, the drug did not affect all parameters. In addition, markers for liver and kidney functions did not meaningfully change in all treated groups. Since there were no adverse effects from the drug in a single-dose intraperitoneal toxicity test, it was concluded that the lethal dose 50 (LD50) of Vital-Shoot is estimated to be >2,000 mg/kg BW.
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