치주염 조직에서 발현이 증가하는 CTGF에 의한 파골세포 생존 증가
(주)코리아스칼라
- 최초 등록일
- 2023.04.05
- 최종 저작일
- 2017.08
- 8페이지/ 어도비 PDF
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 41권 / 4호
ㆍ저자명 : 한혜연, 박종철, 유미현, 배문경, 김형준
영어 초록
Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.
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