한우고기 내 불포화지방산 조성 관련 Stearoyl-CoA Desaturase 유전자 효과 추정

서지정보

ㆍ발행기관 : 강원대학교 동물자원공동연구소 ㆍ수록지정보 : 동물자원연구 / 21권 / 1호
ㆍ저자명 : 이승환, 조용민, 임다정, 이현정, 최봉환, 장길원, 이경태, 김남국, 허강녕, 오성종, 김태헌, 윤두학

목차

ABSTRACT I. 서론 II. 재료 및 방법 1. 공시재료 2. 지방산조성 3. SNP검출 및 유전자형 결정 4. Haplotype 구성 5. 동맥경화 및 혈전형성 지수식 도출 6. 통계분석 III. 결과 및 고찰 1. 지방산조성에 따른 표현형 상관관계 2. SCD유전자 변이(SNP)와 혈전형성 및 동맥경화지수간의 연관성 분석 3. SCD유전자 변이 일배체형 효과 IV. 요약 V. 인용문헌

영어 초록

This study aims to identify DNA marker related to health index which is derived from fatty acid composition of Hanwoo meat. We investigated a genetic association between two SNPs (-867G>C and 878C>T) of SCD gene and health indexes. Two health index values (index of atherogenicity and index of thrombogenicity) were derived from a combination of fatty acid composition. Phenotypic correlation indicated that oleic acid (C18:1) was negatively correlated to index of atherogenicity (-0.84) and index of thrombogenicity (-0.91), respectively. Statistical analysis revealed that 878T>C SNP was significantly associated with IA (index of atherogenicity, p=0.012) and IT (index of thrombogenicity, p=0.006). There was no association between the regulatory SNPs (-867G>C and -877Gdel) and health indexes. Haplotype analysis detected 4 main haplotype (GdelT; 0.004, GdelC; 0.344, CGT; 0.350 and CGC; 0.261) in Hanwoo. The GdelT haplotype was significant on IA and IT. The effect of GdelT haplotype showed increasing IA and IT values, while GdelC haplotype has a decreasing IA and IT value in Hanwoo. In conclusion, the 878C>T SNP in the SCD gene seems to have an effect on this health index and might be implemented into animal breeding program.

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