Wood Vinegar Exerts Hypoglycemic Effect in Normal and Diabetic Rats
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서지정보
ㆍ발행기관 : 강원대학교 동물자원공동연구소
ㆍ수록지정보 : 동물자원연구 / 18권
ㆍ저자명 : Yu Xin Yang, Ji Soon Yong, Jae Yong Choi, Lokahare Jayant, Byung Jo Chae
ㆍ저자명 : Yu Xin Yang, Ji Soon Yong, Jae Yong Choi, Lokahare Jayant, Byung Jo Chae
목차
ABSTRACT Ⅰ. Introduction Ⅱ. Materials and Methods 1. Wood vinegar preparation 2. Animals, experimental design, diets and management 3. Measurements 4. Statistical analysis Ⅲ. Results and Discussion 1. Body weight, feed and fluid intake 2. Blood glucose, urine glucose and urine pH Acknowledgement Ⅳ. References영어 초록
Wood vinegar, an extract from Acer Tegmentosum Maximowicz, was evaluated for its hypoglycemic and anti-diabetic properties by using normal and diabetic rats. The extract was dissolved in water and administered daily for six or seven weeks. In experiment 1, thirty normal Sprague- Dawley (SD) male rats were randomly divided into five treatments of 6 rats each. The treatments were T1 (mineral water), T2 (mineral water), T3 (silver solution), T4 (wood vinegar), and T5 (silver solution + wood vinegar) and diabetes was induced by intravenous injection of streptozotocin except T1. In experiment 2, sixteen diabetic Goto-Kakizaki (GK) male rats were randomly divided into four treatments of 4 rats each. The treatments were T1 (mineral water), T2 (silver solution), T3 (wood vinegar), and T4 (silver solution + wood vinegar). Streptozotocin-induced diabetic rats showed less body weight gain, more food intake and less water consumption as compared with normal non-diabetic rats. Oral administration of wood vinegar resulted in more weight gain, lower blood glucose concentration and urine pH among all the diabetic rats. In experiment 2, diabetic GK rats administrated with wood vinegar showed higher weight gain, food intake and less water intake when compared with control. However, supplementation with wood vinegar did not result in any decrease of blood glucose concentrations. It could be concluded that wood vinegar extracted from Acer Tegmentosum Maximowicz exerted hypoglycemic effect in diabetic-induced normal rats, but not in diabetic GK rats.참고 자료
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