Reactive Oxygen Species are Involved in Y-27632-induced Neurite Outgrowth in PC12 Cells
(주)코리아스칼라
- 최초 등록일
- 2023.04.03
- 최종 저작일
- 2016.12
- 6페이지/ 어도비 PDF
- 가격 4,000원
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 대한구강생물학회
ㆍ수록지정보 : International Journal of Oral Biology / 41권 / 4호
ㆍ저자명 : So Yeong Park, Seong Ah Moon, Jeong Mi An, Du sik Kim, Jeong Taeg Seo
영어 초록
Inhibition of Rho-associated coiled coil-containing kinase (ROCK) has been reported to promote differentiation of neuronal cells. Here, we examined the effect of Y-27632, a ROCK inhibitor, on the outgrowth of neurites in PC12 cells. Y-27632 caused a rapid induction of neurite outgrowth in PC12 cells in a time-dependent manner. The neurite outgrowth, triggered by Y-27632, was accompanied by Rac1 activation, and was attenuated by Rac1 inhibitor NSC23766, in a concentration-dependent manner. Y-27632 also induced an increase in the production of reactive oxygen species (ROS). Pretreatment with N-acetylcysteine, an ROS scavenger, inhibited the ROS generation and neurite outgrowth in response to Y-27632. These results indicate that the activation of Rac1 and the generation of ROS contribute to the neurite outgrowth triggered by Y-27632 in PC12 cells.
참고 자료
없음
"International Journal of Oral Biology"의 다른 논문
더보기 (5/10)