Antimicrobial activity of Garcinia mangostana L. ethanol extract against Cutibacterium acnes and Staphylococcus aureus

서지정보

ㆍ발행기관 : 대한구강생물학회 ㆍ수록지정보 : International Journal of Oral Biology / 44권 / 3호
ㆍ저자명 : Yun Kyong Lim, So Young Yoo, Soon-Nang Park, Dae Sung Lee, Joong-Ki Kook

목차

Introduction
Materials and Methods
1. 세포독성실험
2. 세균 및 세균 배양
3. 최소살균농도(minimum bactericidal concentration, MBC) 값 측정
Results
1. HEK 293 세포주에 대한 세포 독성
2. 망고스틴 추출물의 항균 활성 효과
Discussion
References

영어 초록

The purpose of this study was to investigate the antimicrobial activity of the ethanol extract of Garcinia mangostana L. (mangosteen) against Cutibacterium acnes (6 strains) and Staphylococcus aureus (6 strains). The antimicrobial activity of the mangosteen extract was evaluated based on its minimal bactericidal concentration. Cytotoxicity of the mangosteen extract against human embryonic kidney 293 (HEK 293) cells was determined using the cell counting method. The data showed that the mangosteen extract was not toxic to HEK 293 cells at a concentration of up to 16 μg/mL and killed 87.0% and 99.9% of C. acnes and S. aureus after 10 minutes and 1 hour of treatment, respectively. These results suggest that ethanol extract of mangosteen can be used as an anti-acne agent.

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