Porphyromonas gingivalis-감염 구강편평세포암종 세포에서의 mRNA 발현 변화
(주)코리아스칼라
- 최초 등록일
- 2016.04.02
- 최종 저작일
- 2013.12
- 12페이지/ 어도비 PDF
- 가격 4,300원
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 37권 / 6호
ㆍ저자명 : 박지은, 우복희, 박대근, 박봉수, 이지혜, 박혜련
목차
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
1. Bacteria and culture conditions
2. Oral squamous cell carcinoma cell culture
3. Bacterial infection
4. RNA isolation
5. Labeling and purification
6. Hybridization
7. Raw data preparation and Microarray DataAnalysis
Ⅲ. RESULTS
1. Global Gene Expression Profiles
2. Ontology analysis
Ⅳ. DISCUSSION
Ⅴ. REFERENCES
영어 초록
Chronic inflammation is widely considered to predispose individuals to cancer. Microorganisms facilitate recruitment and activation of inflammatory cells and thus allow release of inflammatory mediators. These molecules can then promote accumulation of mutations, leading to tumor development in the host. Porphyromonas gingivalis, a pathogen causing chronic periodontitis, is detected in oral squamous cell carcinoma (OSCC) tissues. Considering a strong link between chronic inflammation and tumor development, functional consequences of P. gingivalis infection may include malignant transformation of the host cells. In this study, we monitored transcriptional changes induced by invasion of P. gingivalis in OSCC cells using microarrays. Our preliminary results suggest changes in a wide range of genes involved in inflammation, apoptosis and autophagy, tumor progression, and carcinogenesis. Further studies on molecular mechanisms underlying these changes will lay a useful foundation to elucidate the role of microorganism-related inflammation and for the development of preventive and therapeutic agents for oral cancer.
참고 자료
없음