편평상피세포암에서 E-cadherin/beta catenin 발현 및 예후, 전이, 재발에 미치는 영향
(주)코리아스칼라
- 최초 등록일
- 2016.04.02
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- 2011.12
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서지정보
ㆍ발행기관 : 대한구강악안면병리학회
ㆍ수록지정보 : 대한구강악안면병리학회지 / 35권 / 6호
ㆍ저자명 : KM Ahsan Kabir, 김서연, 임원봉, 김지선, 고영종, 김상우, 오미라, 오희균, 최홍란, 김옥준
목차
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
1. Samples
2. Data entry
3. Antibodies and reagents used andtheir specifications
4. Immunohistochemical procedures
5. Immunolabelling protocol
6. Statistical analysis
Ⅲ. RESULTS
1. Distribution of cases according to gender and age
2. Distribution of cases according to the stage ofcancer
3. Distribution of cases according to the treatment
4. Expression of E-cadherin, β-catenin andphospho β-catenin in cancer islands
5. Comparison of stains between different groups
6. Recurrence and metastasis status andlocalization of stain
7. Histological differentiation and staining
8. Survival analysis
Ⅳ. DISCUSSION
Ⅴ. REFERENCES
영어 초록
Recurrence-metastasis status of squamous cell carcinoma of tongue is a challenging oncologic problem. This study examined the expression of E-cadherin/β-catenin cell adhesion complex in squamous cell carcinoma of the tongue through an immunohistochemical study. Twenty samples from 15 patients with squamous cell carcinoma of the tongue, who were treated at the Department of Oral and Maxillofacial Surgery, consisted of primary or recurrent tumors along with matched metastatic lymph nodes were retrieved for immunohistochemical staining and grouped based on recurrence-metastasis status.Differences in stain localization were noted in E-cadherin, β–catenin and phospho β–catenin staining between different tumor groups based on the recurrence-metastasis status. The number of phospho β-catenin stain positive cells was found to have a significant role in survival. E-cadherin confirms its role as a powerful individual differentiation indicator and the role of β-catenin specially the phospho type elicts interest
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