마늘성분 SAC 및 Hydrogen Peroxide에 의한 줄기세포의 유전자 발현 윤곽
(주)코리아스칼라
- 최초 등록일
- 2016.04.01
- 최종 저작일
- 2012.12
- 8페이지/ 어도비 PDF
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서지정보
ㆍ발행기관 : 한국식품영양학회
ㆍ수록지정보 : 한국식품영양학회지 / 25권 / 4호
ㆍ저자명 : 박란숙
영어 초록
Though hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) causes a deleterious effect to cells with its reactive oxygen species resulting in cell death, S-allyl cysteine (SAC, a bioactive organosulfur compound of aged garlic extract) has been known to have a cytoprotective effect. Few reported profiles of gene expression of H<sub>2</sub>O<sub>2</sub> and SAC treated human cord blood derived mesenchymal stem cells (MSC). This study revealed changes in the profile of twenty-one genes grouped by oxidative stress, antioxidant, cell death, anti-apoptosis and anti-aging by quantitative real time PCR. A concentration of 100μM of SAC or 50μM of H<sub>2</sub>O<sub>2</sub> was applied to MSC which show moderate growth and apoptosis pattern. H<sub>2</sub>O<sub>2</sub> treatment enhanced expression of eleven genes out of twenty-one genes compared with that of control group, on the contrary SAC suppressed expression of eighteen genes out of twenty-one genes except C ros oncogene. SAC decreased expression of oxidative stress genes such as SOD1, CAT and GPX. These results seemed consistent with reports which elucidated over expression of NF-kB by H2O2, and suppression of it by SAC. This study will confer basic information for further experiments regarding the effects of SAC on gene levels.
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