자유로운 신체운동과 멜라토닌이 우울장애 동물모델에 미치는 효과
(주)학지사
- 최초 등록일
- 2015.04.08
- 최종 저작일
- 2015.02
- 7페이지/ 어도비 PDF
- 가격 3,000원
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 기초간호학회
ㆍ수록지정보 : 기초간호자연과학회지 / 17권 / 1호
ㆍ저자명 : 성호현, 정성모, 김시원, 김연정
목차
서 론
연구 방법
연구 결과
논 의
결 론
REFERENCES
영어 초록
Stress, depending on its intensity and duration, results in either adaptive or maladaptive physiological and psychological changes in humans. Also, it was found that stressful experiences increase the signs of behavioral despair in rodents. On the other hand, exercise and melatonin treatment is believed to have many beneficial effects on health. Thus, this study was designed to evaluate the anti-depressant effects of physical activity and melatonin against chronic stress-induced depression in rats. Methods: Adult male Sprague-Dawley(SD) rats(200-250g, 7 weeks of age) were subjected to depression induced by chronic stress. Chronic depression was induced with forced-swim stress (FSS) and repeated change of light-dark cycle for 4 weeks. In the last 2 weeks, some rats were confined in a cage enriched with a running wheel, seesaw and chewed a ball from 19:00 to 07:00 every day. Melatonin was injected intra-peritoneally (I.P), and the rats received intraperitoneal injections of melatonin (15 mg/kg). The Forced Swim Test (FST) was performed to evaluate the immobility behaviors of rats for a 5 min test. Results: It was found that, the immobility time in FST was significantly (p<.05) lower in physical exercise (M=58.83±22.73) and melatonin (M=67.33±37.73) than in depressive rats (M=145.93±63.16) without physical activity. Also, TPH positive cell in dorsal raphe was significantly (p<.05) higher in exercise (M=457.38±103.21) and melatonin (M=425.38±111.56) than in depressive rats (M=258.25±89.13). Conclusion: This study suggests that physical activity and melatonin produces antidepressant-like effect on stress-induced depression in rats. So, physical exercise and melatonin may be a good intervention in depression patients.
참고 자료
없음
"기초간호자연과학회지"의 다른 논문
더보기 (4/9)