스테로이드 치료 후 회복기의 규칙적인 운동이 쥐의 스테로이드 유발성 위축 뒷다리근에 미치는 영향

서지정보

ㆍ발행기관 : 기초간호학회 ㆍ수록지정보 : 기초간호자연과학회지 / 4권 / 1호
ㆍ저자명 : 최명애, 변영순, 황애란, 김희승, 홍해숙, 최스미, 서화숙, 이경숙, 박미정, 신기수, 안경주, 이윤경, 임지희

목차

Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 연구결과
Ⅳ. 논의
Ⅵ. 결론
참고문헌

영어 초록

This study was conducted to determine whether low intensity regular exercise following steroid treatment could attenuate steroid-induced muscle atrophy. Thirty-eight Sprague-Dawley rats weighing 165~175g were divided into six groups ; control group(C), dexamethasone administration group(D), sedentary after normal saline administration group(C+Se), exercise after normal saline administration group(C+Ex), sedentary group after dexamethasone administration(D+Se), exercise group after dexamethasone administration(D+Ex). Either dexamethasone(5mg/kg) or normal saline was injected for 7days accordingly. Exercise was started at 10m/min on the 10° grade treadmill and gradually increased up to 15m/min by the 7th day for 60minutes/day(20min×3). The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSS WIN 9.0 program.
Body weight, muscle weight and myofibrillar protein content of both plantaris and gastrocnemius, Type Ⅰ, Ⅱ muscle fiber cross-sectional area of plantaris, and Type Ⅱ muscle fiber cross-sectional area of gastrocnemis in D group were significantly lower than those of C group(p<.05) respectively. Hindlimb muscle weight, myofibrillar protein content of both plantaris and gastrocnemius, Type Ⅰ muscle fiber cross-sectional area of soleus and Type Ⅰ, Ⅱ muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of D+Se group. Myofibrillar protein content of both plantaris and gastrocnemius, Type Ⅰ muscle fiber cross-sectional area of plantaris in D+Ex group tended to increase compared to those of C+Se group.
Based on these results, it is suggested that regular low-intensity exercise during recovery period after steroid treatment might facilitate the recovery from steroid-induced muscle atrophy.

참고 자료

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