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Transcriptional regulators of hematopoiesis

Identification of Hematopoietc Stem Cells
Stem cells cannot be distinguished from other cells in the bone marrow using a simple microscope.

Neural stem cells
Existence of fetal neural stem cells
Adult neural stem cells initially controversial now accepted
Identified by culturing brain and looking for
Proliferation in culture
Ability to differentiate in to many cell types after transplantation
Proliferate
Migrate
In some cases can populate and replace tissue in damaged brain or spinal cord

Potential of differentcells for neural differentiation

Neural stem cells derived from hippocampus can populate other brain tissue
Marked adult Hippocampal cells grafted to adult Hippocampus and Olfactory bulb. Marked with TH

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