(prelab,예비&labreport,결과)8. Suzuki-Miyaura Cross-Coupling for the Synthesis of a Biaryl

소개글

"(prelab,예비&labreport,결과)8. Suzuki-Miyaura Cross-Coupling for the Synthesis of a Biaryl"에 대한 내용입니다.

목차

1. Objectives
2. Principles & Methods
3. Table of relevant chemical properties
4. Results
5. Discussion

본문내용

Objectives: Synthesize biaryl by Suzuki-Miyaura cross-coupling rxn and predict the product by measuring the m.p. Understand the mechanism of Suzuki-Miyaura cross-coupling rxn and organic synthesis using Pd cat.

Principles & Methods : In this exp, we will use a Pa cat. to synthesize biaryl compounds using the Suzuki rxn, which is one of the types of cross-coupling rxns. Before studying the Suzuki rxn, let's find out how the Pd cat. participates in the organic rxn. Pd chemistry mainly occurs in two oxidation states: the zero-valent state[Pd(0), d10] and the +2-valent state[Pd(II), d8].

참고 자료

Gorge S, Zweifel, Michael H. Nantz, Peter Somfai 『Modern Organic Synthesis ; An Introduction / 2nd ed』. 285-288pg, 292pg, 295-299pg
Hill, N. J.; Bowman, M. D.; Esselman, B. J.; Byron, S. D.; Kreitinger, J.; Leadbeater, N. E. J. Chem. Educ. 2014, 91, 1054–1057. DOI: 10.1021/ed400531w
Hamilton, A. E.; Buxton, A. M.; Peeples, C. J.; Chalker, JM. J. Chem. Ed. 2013, 90, 1509–1513. DOI: 10.1021/ed4002333
Miyaura, N.; Suzuki, A. Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds. Chem. Rev. 1995, 95, 7, 2457-2483. DOI: 10.1021/cr00039a007
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