질병을 유발하는 면역기전과 치료 Immune Defense System

소개글

질병을 유발하는 면역기전에 대한 간단한
설명과 대표적인 관련diseases에 대한 치료와 발병기전 정리자료입니다.

목차

1. Neuroimmunology
2. Immune mechanisms of skin disorders
3. Immune Defense System: Innate & Adaptive Immunity
4. Autoimmune diseases: Rheumatic diseases
5. Atopic dermatitis

본문내용

<Immune System/Organs>
⋅Primary lymphoid organs – Myeloid cells, Lymphoid cells
⋅Secondary lymphoid organs

<Immune cells>
⋅Hematopoietic stem cell
- Myeloid progenitor→Dendritic cell, Macrophage, Neutrophil, Eosinophil, Basophil, Platelets, Erythrocyte
- Lymphoid progenitor→T cell, B cell, Dendritic cell

<Immune Defense System>
⋅Skin, Mucous membrane(GI, respiratory) 통해 Antigen 침입시 Bone marrow, Thymus에서 Naive B, T cell 생성하여 Spleen, Lymph node로 이동, Dendritic cell capture 통하여 Adaptive Immunity

<Innate Immnunity: Pattern Recognition Receptors>
⋅PRR: TLR,RLR,NLR→Cytokine(IL, IFN, TNF)→Inflammation→Clearance of invading pathogens-repairs of damaged tissue

<Lymphocyte Activation>
⋅B cell은 T cell이 활성화 시킴(CD4+)

<Effector Lymphocytes: Humoral/Cellular Immunity>
⋅Humoral: Plasma cell-B cell의 phahocyte, NK cell
⋅Cellular: CD4 T cell- Th1, Th2, Th17, Treg
CD8 T cell- Cytotoxic T lymphocytes

참고 자료

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