ASCB mini symposium

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Mini symposium Stress Responses
Allosteric Activation of IRE1 via a Novel Ligand Binding Poket.
Disruption of the Q-site prevents Quercetin-mediated activation of IRE1 Rnase activety.

Binging the Q-site increases the population of IRE1 dimer.

Quercetin activates IRE1 Rnase independent of phosphorylation.

The Q-site is a novel ligand bindig poket on yeast IRE1.

Ligands that bind the Q- site can modulating IRE signal.

Membrane Expansion Alleviates ER stress independently of the unfolded protein response.

ER homeostasis : the unfolded protein responses (UPR)

the UPR controls ~5% of all genes in yeast.

ER stress induced ER membrane expansion.

-> DTT로 stress 주었을 시에 membrane이 expansion.

ER stress induces the formation of new ER sheets.

ER stress induces comprehensive ER remodeling.

Regulation of ripid biosynthesis in yeast

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