Adhesion and Tropism
- 최초 등록일
- 2012.04.24
- 최종 저작일
- 2011.01
- 30페이지/
MS 파워포인트
- 가격 1,000원
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Adhesion and Tropism of Respiratory Bacteria
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본문내용
Host의 여러 component는 bacteria가 부착하기 위한 target이 된다.
Fibronectin(Fn)
Plasminogen
mucus
Ig superfamily
Selectin
Cadherin
Proteoglycan
(syndecan, glypican, epiglycan)
The tripeptide Arg-Gly-Asp (RGD) was originally identified as the sequence within fibronectin that mediates cell attachment. The RGD motif has now been found in numerous other proteins and supports cell adhesion in many, but not all, of these. The integrins, a family of cell-surface proteins, act as receptors for cell adhesion molecules. A subset of the integrins recognize the RGD motif within their ligands, the binding of which mediates both cell-substratum and cell-cell interactions. RGD peptides and mimetics, in addition to providing insights into the fundamental mechanisms of cell adhesion, are potential therapeutic agents for the treatment of diseases such as thrombosis and cancer.
참고 자료
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