Mitochondrial oxidative stress regulatory approaches for diabetic encephalopathy
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서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical and Translational Research / 23권 / 4호
ㆍ저자명 : Hye Jih Kim, Dae Hyun Kim, Hang Hyo Jo, Hyun Jik Lee
ㆍ저자명 : Hye Jih Kim, Dae Hyun Kim, Hang Hyo Jo, Hyun Jik Lee
목차
AbstractGeneral introduction of diabetic encephalopathy
Glucose transporter (GLUT) in diabetic encephalopathy
Effect of high glucose on neurodegeneration
Mitochondrial oxidative stress in diabetic encephalopathy
Effect of high glucose on mitochondrial dynamics and nuclearfactor erythroid 2–related factor 2 (Nrf2)-regulatedantioxidative system
Role of calcium in diabetic encephalopathy
Role of O-linked-N-acetylglucosaminylation (O-GlcNAcylation)in diabetic encephalopathy
Role of glycogen synthase kinase 3β (GSK3β) signaling indiabetic encephalopathy
Conclusion
REFERENCES
영어 초록
Diabetic encephalopathy is a major complication with cognitive impairment and neurodegeneration in patients with type 1 or type 2 diabetes mellitus (DM). DM-induced glucolipotoxicity is a risk factor for Alzheimer’s disease–like phenotype, including amyloidogenesis, tau hyperphosphorylation, and neuronal apoptosis. Although the detailed mechanism underlying the pathogenesis of diabetic encephalopathy remains unclear, mitochondrial oxidative stress is emerging as a key factor for diabetic complications and neurodegeneration. A deeper understanding of the regulatory mechanism of mitochondrial oxidative stress under hyperglycemic conditions will provide insights into the development of therapeutic strategies for diabetic encephalopathy. Here, we review the role of mitochondrial oxidative stress in diabetic encephalopathy and the regulatory mechanisms by which high glucose induces the generation of mitochondrial reactive species oxygen species in neuronal cells. This review also summarizes the mitochondrial-dependent and -independent pathways (O-linked-N-acetylglucosaminylation, calcium, and glycogen synthase kinase 3β signaling) that regulate mitochondrial oxidative stress in a DM model.참고 자료
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