녹차 카테킨류의 혈관장력 및 Ca2+ 유입에 미치는 영향
(주)코리아스칼라
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- 2023.04.05
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- 1996.06
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서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 11권 / 2호
ㆍ저자명 : 안희열, 이미애, 윤여표
영어 초록
The objective of this study is to investigate the direct effects of green tea catechins(GTC) on vascular smooth muscle tension and ^(46)Ca^(2+) uptake in rat aorta. The methods used in this study are isometric tension measurements using physiograph, Lanthanum method for ^(46)Cac^(2+) (2 uCi/ml) uptake measurement in rat aorta. GTC modified tension induced by 40 mM KCl or 1 uM norepinephrine in rat aorta. Low concentrations of GTC($lt;0.5 mg/m increased tension by 40 mM KCl or 1 tM norepinephrine, individually. However, high concentrations of GTC($gt; 0.5 mg/ml) inhibited tension by 40 mM KCl or 1 uM norepinephrine, individually. GTC increased ^(45)Ca uptake induced by 40 mM KCl in a dose-dependent manner. From these results, GTC has the dual actions in vascular smooth muscle in vitro. Low concentrations of GTC augments tension by K or norepinephrine. However, high concentrations of GTC inhibits tension by K or norpeinephrine. GTC may have Ca^(2+) channel activation action, which may result in unphysiological vasodilation by Ca^(2+) overload in vascular smooth muscle.
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