Participation of Opioid Pathway in the Central Antinociceptive Effects of Eugenol

서지정보

ㆍ발행기관 : 대한구강생물학회 ㆍ수록지정보 : International Journal of Oral Biology / 43권 / 3호
ㆍ저자명 : Song-hee Kang, Sa-won Kang, Jae-ho Kim, Hee-young Kim, Hyeon-seo Ryu, So-yeon Bae, Ju-ae Oh, Jun-hyuk Lee, Ji-hee Hyun, Dong Kuk Ahn

목차

서 론
재료 및 방법
실험동물
포르말린 테스트
척수강으로 약물주입(Intrathecal catheterization)
실험에 사용한 약물들
통계분석
실험 결과
고 찰
References

영어 초록

The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5% formalin-induced nociceptive behavioral responses was used as the pain model. Subcutaneous injection of 5% formalin significantly produced nociceptive responses by increasing the licking time during nociceptive behavior. Subsequent intraperitoneal injection of 100 mg/kg of eugenol led to a significant decrease in the licking time. However, low dose of eugenol (50 mg/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. Intrathecal injection of 30 μg of naloxone, an opioid receptor antagonist, significantly blocked antinociceptive effects produced by intraperitoneal injection of eugenol. Neither intrathecal injection of methysergide (30 μg), a serotonin receptor antagonist nor phentolamine (30 μg), an α-adrenergic receptor antagonist influenced antinociceptive effects of eugenol, as compared to the vehicle treatment. These results suggest that central opioid pathway participates in mediating the antinociceptive effects of eugenol.

참고 자료

없음