Protective effect of halophyte Salsola komarovi Iljin against gastric ulcer Induced by alcohol treatment in rats

서지정보

ㆍ발행기관 : 충북대학교 동물의학연구소 ㆍ수록지정보 : Journal of Biomedical Research / 15권 / 4호
ㆍ저자명 : Sunhwa Hong, Hyun-A Lee, Yun-seong Lee, Dong-Woo Kim, Gi-Wook Oh, Jiwan Woo, Yakdol Cho, Jae-Hyeok Jeong, Okjin Kim

목차

Introduction
Materials and Methods
실험재료
실험동물
군 분리 및 시료의 투여
HCl-ethanol 위염 모델 유도 및 관찰
육안적 측정
위궤양 억제율 계산
위 조직의 병리학적 관찰
통계처리
Results
HCl-ethanol 모델에서 육안적 소견
HCl-ethanol 모델에서 위 점막 손상 결과
위 조직 병리학적 변화
Discussion
ORCID
References

영어 초록

Salsola komarovi Iljin is a halophyte and herbaceous annual native to the sand dunes and beaches of Japan, northern China, Sakhalin, and Korea. The plants have been known as an ecologically important species for enhancing formation of sand dunes in Korea. The purpose of this study was to examine the anti-gastric ulcer effect of Salsola komarovi Iljin halophyte in an HCl-ethanol-induced gastritis model. SD rats (7-weeks-old) were divided into normal (I, n=10), control (II, 60% HCl-ethanol + water, n=10), 60% HCl-ethanol + Ranitidine 300 mg/kg (III, n=10), 60% HCl-ethanol + Salicornia herbacea L. 500 mg/kg (IV, n=10), 60% HCl-ethanol + 50% alcohol extract of Salsola komarovi Iljin 500 mg/kg (V, n=10), and 60% HCl-ethanol + water extract of Salsola komarovi Iljin 500 mg/kg (VI, n=10) groups. Salsola komarovi Iljin significantly suppressed gastric lesions and ulcers in the 60% HCl-ethanol-induced gastric model. Especially, 500 mg/kg of 50% alcohol extract of Salsola komarovi Iljin showed significant inhibitory effects against gastritis. Especially, 50% alcohol extract of Salsola komarovi Iljin 500 mg/kg showed a significantly inhibitory effect, which was more potent than that of 300 mg/kg of Ranitidine. In histopathological analysis of the animal model, Salsola komarovi Iljin attenuated gastric ulcer formation. Our results suggest that Salsola komarovi Iljin has inhibitory effects against gastritis and gastric ulcers and could be developed as a new anti-gastric ulcer agent.

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