Fission Yeast : Schizosaccharomyces Pombe
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Fission Yeast: Schizosaccharomyces PombeIntroduction
First found from East African millet beer more than a century ago, Schizosaccharomyces pombe has many genes associated with human diseases such as cancers, cystic fibrosis, hereditary deafness, and diabetes. It is known to be rod shaped and is about two to three microns in diameter and seven to fourteen microns in length. The name Schizosaccharomyces was assigned to show the common characteristics such as spore formation and fermentation. Schizo, means "different", and the word pombe was due to its isolation from beer, as pombe essentially means "from beer", in Swahili (Birgit 2001).
S. pombe is used in this experiment because it is simple, single celled eukaryotes, and undergoes cell division cycle like human cells. In addition, it is a small genome and has a fast doubling time. Particularly, haploid cells were used since they are able to adapt to the presence of an unrepaired single double strand break and progress through the cell cycle after a delay of several hours,
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