Spontaneous pulmonary alveolar proteinosis in a C57BL/6 mouse: Case report
(주)코리아스칼라
- 최초 등록일
- 2023.12.04
- 최종 저작일
- 2023.06
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서지정보
ㆍ발행기관 : 한국예방수의학회(구 한국수의공중보건학회)
ㆍ수록지정보 : 예방수의학회지 / 47권 / 2호
ㆍ저자명 : Warisraporn Tangchang, Eun-Sang Cho, Won Kee Yoon, Hyo-Jung Kwon, Hwa-Young Son
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감사의 글
영어 초록
This case report describes the pathological features of pulmonary alveolar proteinosis(PAP) in mouse. Grossly, multiple irregular yellow-grey patches were observed on the lung surface of a C57BL/6 mouse. Histopathologically, the alveolar walls were thickened by type II cell hyperplasia and cellular infiltrates, and the bronchioles and alveolar lumens were filled with amorphous eosinophilic lipoproteinaceous material. This material was positive for Periodic acid-Schiff stain. Gomori methenamine silver staining was negative. Immunohistochemical staining showed that cells in the alveolar wall and lumen were positive for surfactant protein B, chitinase-like protein-3, and CD68. As a result, PAP was diagnosed. This is a rare case of spontaneous PAP in mice, and we report the histopathological characteristics along with the literature.
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