Coronavirus disease 2019 as a systemic disease: a review

서지정보

ㆍ발행기관 : 충북대학교 동물의학연구소 ㆍ수록지정보 : Journal of Biomedical and Translational Research / 21권 / 4호
ㆍ저자명 : Hoon Kang, Donggeun Lee, Jinsol Lee

목차

Introduction
Systemic Effects of COVID-19
Pulmonary system
Cardiovascular system
Genitourinary system
Digestive system
Neurologic system
Intensive care unit
Special Occasions with COVID-19
Pregnant women
Neonates
BCG vaccination and SARS-CoV-2
Proton pump inhibitor (PPI) and COVID-19
Cancer
Obesity
Diagnosis
Treatment
Chloroquine
Hydroxychloroquine
Remdesivir
Convalescent plasma
Lopinavir-ritonavir
Dexamethasone
Prevention/vaccine
Discussion
References

영어 초록

Since a cluster of pneumonia cases of unknown etiology was first reported in China in December 2019, the number of confirmed cases with coronavirus disease 2019 (COVID-19) (caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) worldwide has been increasing, and nearly two million patients are expected to have died by February 2021. Globally, COVID-19 is being considered a primary pulmonary disease, but it is more than a lung infection. This is because patients infected with SARS-CoV-2 present with a variety of clinical signs and symptoms involving many organs, ranging from fever, inflammation, myocardial injury, shock, and the development of coronary artery aneurysm. SARS-CoV-2 shows unique characteristics in its transmission, mortality, and stability in different environmental conditions. During COVID-19 pandemic, about 10 drugs have been clinically tried with none proven to be effective. With no prospect for effective drugs in the near future, there are currently possibilities of success with vaccines and convalescent plasma. Along with the prospect of vaccines and other therapeutic drugs, special precautions (isolation, testing, treating, and tracing) are strictly recommended until we return to normal situations. In this review we comprehensively analyzed the clinical presentations, characteristics, and outcomes of patients with COVID-19, and tried to assess the clinical effects of some drugs as part of the ongoing efforts to understand COVID-19 pandemic.

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