Haploidy of somatic cells in mouse oocyte using somatic cell nuclear transf
(주)코리아스칼라
- 최초 등록일
- 2023.04.24
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- 2022.12
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서지정보
ㆍ발행기관 : 한국수정란이식학회
ㆍ수록지정보 : Journal of Embryo Transfer / 37권 / 4호
ㆍ저자명 : Yeonmi Lee, Eunju Kang
목차
ABSTRACT
INTRODUCTION
CONCLUDING REMARKS AND FUTUREPERSPECTIVES
REFERENCES
영어 초록
Haploidization in somatic cells is the process of reducing the diploid somatic chromosomes to haploid. Several studies have attempted somatic haploidization using oocytes in mice and humans. Some researchers showed partial somatic haploidization, but none observed embryo development. Our study attempted somatic haploidization using the modified somatic nuclear transfer (SCNT) protocol with various combinations of chemicals or proteins in mice. This study induced the proper segregation of somatic homologous chromosomes and full embryo development in vitro. Furthermore, somatic haploid embryos established embryonic stem cells and produced live births. The current review summarizes this recent study on the success of somatic haploidization and provides an overview of other related studies on somatic haploidization.
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