Effect of Heme oxygenase-1 inducer and inhibitor on BN Rat Choroidal Neovascularization Model

서지정보

ㆍ발행기관 : 대한시과학회 ㆍ수록지정보 : 대한시과학회지 / 8권 / 1호
ㆍ저자명 : Jang Jung Un, Lee Sook Hee, Doo Ha Yoog, Yang Yun Sik

한국어 초록

본 논문의 연구목적은 Choroidal neovascularization (맥락막 신생혈관) 모텔에서 HO-1 발현제와 억제재의 영향을 알아보고자 한다. 30마리의 Brown Norway rat을 각각 10마리씩 세 그룹， Hemin treated group, SnPP treated group, Contorl group으 로 나누어서 실험을 진행하였다. Hemin treat group은 10μmol/kg hemin(Frontier Scientific Inc. USA) 을 SnPP treat group은 10 μmol/kg SnPP(Frontier Scientific Inc. USA)을 laser 시술 2 일에서 14 일까지 복강내 주사하였고 Control군은 0.5 mß씩 식 염 수를 주사하였다. 14 일 후 안저사진촬영과 형광안저촬영을 실시하였다. SnPP treated group에서 Hemin treated group보다 더 많은 선생혈관이 생성되었다. Hemin treated group에서는 맥락막 신생혈관 형성의 정도가 정상대조군에 비교하여 저하됨을 알 수 있었다. 본 연구의 결과 HO-1 의 inducer 인 Hemin 이 맥락막의 신생혈관 억제에 영향을 미치는 것으로 보여진다.

영어 초록

The purpose of this study to investigate the effects of HO-1 inducer and HO-1 inhibitor in treating Brown Norway rat Choroidal neovascularization model. Thirty male Brown Norway rat divided each ten; 10 were served as HO-1 inducer, Hemin (Hemin treated group) other 10 were treated with an HO-1 inhibitor, SnPP(SnPP treated group) and the 10 remnant was control group. Rats were given either 10 ttrnol/kg hemin(Frontier Scientific Inc. USA) or 10 μrnol/kg SnPP(Frontier Scientific Inc. USA) by intraperitoneal injection once daily from 2 to 14days after laser. Control group was injected in each rat was 0.5 rnQ each day. 14days later, fundus photography and fluorescein angiography (F A) were perforrned. Masked F A grading lesion a small in Hemin πeated group. But SnPP treated group were creation new vessel. Our result suggest that endogenous HO-1 plays an important protective role in Choroidal neovascularization and that target induction of HO-1 over expression may present a new therapy for the treatment of Choroida neovascular lzatlOn

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