proliferator-activated receptor γ coactivator-1 α (PGC-1α)-luciferase transgenic mice (TG). ... These results suggest that the body fat-lowering effect of garlic powder might be related to PGC-1α by ... In this study, we generated transgenic mice with a PGC-1α promoter (—970/+412 bp) containing luciferase
Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates the response to hypoxia ... In the present study, we investigated HIF-1α expression in OSCC and the effect of HIF-1α-targeting miRNAs ... We analyzed public databases to explore which miRNAs target HIF-1α expression.
The extract suppressed A. actinomycetemcomitans-induced tumor necrosis factor-α, interleukin (IL)-1β, ... And cysteine-aspartic proteases-1 and IL-1β expression were decreased by the extract. ... Extract was not toxic to THP-1- derived macrophages.
연구결과, HIF-1α 단백질은 집단간 차이를 보이지 않았다(p>.05). ... HIF-1α protein showed no differences between groups(p>.05). ... 유산소성 운동은 실험동물용 트레드밀을 이용하여 수행되었으며 HIF-1α 및 VEGF 단백질은 western blot을 통해 관찰하였다.
때문에 일어나며, α1,3-galactosyltransferase(α1,3-GT) 유전자는 돼지 혈관세포 표면의 Galα(1,3)Gal 당분자 생성에 관여한다. ... Galactose-α1,3-galactose (α1,3-Gal) epitope is synthesized at a high concentration on the surface of ... )에 비해 α1,3-GT 유전자의 발현이 감소하였다.
regulated by HIF-1α. ... We further analyzed HIF-1α, PHD2 and VHL expression in the NAC-pretreated MCT cells and assessed the ... In addition, although EPO protein was found to be expressed in a HIF-1α independent manner in three mouse
The rate constant of the nucleophilic addition of 1-propanethiol to α-phenyl-N-iso-propylnitrone derivatives ... Final product of the addition reaction was α-thiopropyl-p-phenylbenzylideneamine. ... -10.0, proceeded by the competitive addition of 1-propanethiol and propanethiolate.
cells (MSCs) derived from α-1,3-galactosyltransferase (GalT) knock out (GalT KO) pig to confirm their ... -1,3-galactosyl epitopes on the surface of pig cells. ... Bone marrow (BM)-MSCs from GalT KO pig of 1 month old were isolated by Ficoll-Paque PLUS gradient and
In contrast, COX-2 mRNA was expressed in group treated with IL-1α when the embryos were cultured with ... The purpose of this study was to determine effects of oxytocin and interleukin-1α on in vitro development ... , the rate of blastocysts were significantly (p<0.05) higher than those of groups treated with IL-1α
Functional ablation of α1,3-galactosyltransferase (Gal-T KO) of pig which is an enzyme involved in synthesis ... of Gala1-3Galb1-4GlcNAc-R antigen is essentially required to prevent HAR. ... study, we constructed a membrane cofactor protein (MCP) expression cassette under control of human EF1α
In addition, we here found that EGCG regulated HIF-1α expression independent of Raf-1 protein. ... via Raf/MEK/ERK pathway, and the HIF-1α expression is associated with the change of epithelial phenotype ... Taken together with our previous result, the result imply that EGCG is attributed to the HIF-1α expression
