neuron, therefore increasing the ion influx via glutamate receptors. ... slices, to investigate the cellular mechanism of mitochondrial ROS on neuronal excitability. ... In the present study, we used patch clamp recording in the substantia geletinosa (SG) neurons of spinal
(SG) neuron. ... slices of rats to investigate the action mechanisms of O2 ⦁- and NO on the excitability of substantiagelatinosa ... Therefore, ROS and RNS play similar roles in the regulation of the membrane excitability of SG neurons
mitochondrial ROS can induce changes in mem¬brane excitability on spinal substantia gelatonosa (SG) neurons ... , rotenone or antimycin A, resulted in a slowly developing and slight membrane depolarization in SG neurons ... mitochondrial electron transport complex (ETC) substrates and inhibitors on the membrane potential of SG neurons
The superficial dorsal horn, particularly substantiagelatinosa (SG) in the spinal cord, receives inputs ... and increased the neuronal firing frequencies evoked by depolarizing current pulses. ... In the present study, whole cell patch clamp recordings were carried out on SG neurons in spinal cord
(SG) neuronal excitability. ... Patch clamp recording in spinal slices was used to investigate the role of O2˙- and NO on substantiagelatinosa ... suggested that ROS and RNS play distinct roles in the regulation of the membrane excitability of SG neurons
(SG) neurons. ... calcium concentration ([Ca<sup>2+</sup>]<sub>i</sub>) in spinal substantiagelatinosa ... Recent studies indicate that reactive oxygen species (ROS) can act as modulators of neuronal activity
(SG) neurons. ... spinal slices of rats to investigate the effects of O2 ⦁- and NO on the excitability of substantiagelatinosa ... elevated ROS, especially O2 ⦁-, NO and ONOO-, in the spinal cord can increase the excitability of the SG neurons
(SG) neurons. ... application of t-BuOOH caused a reversible membrane depolarization and firing activity in substantiagelatinosa ... Recent studies indicate that ROS can act as modulators of neuronal activity, and are critically involved
Substantiagelatinosa (SG) neurons receive synaptic inputs from primary afferent Aδ- and C-fibers, where ... However, involvement of the crosstalk between cAMP and cGMP in neurons is yet to be addressed. ... dedicated to the molecular mechanism underlying the modulation of excitability or synaptic plasticity in SG neurons
The substantiagelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives many thinmyelinated ... SEG was further found to induce membrane hyperpolarization of the SG neurons of the Vc. ... However, little is yet known about the direct effects of SST on the SG neurons of the Vc in adult mice
The substantiagelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is implicated in the processing ... GABA ( 30-100μM) also induced membrane depolarization of SG neuron. ... SG neurons were depolarized by application of BMI (20M) using a high Cℓ⁻ipette solution.
In this study, we examined the excitability of substantiagelatinosa (SG) neurons of the spinal dorsal ... Glial cells, including astrocytes and microglia, interact closely with neurons and modulate pain transmission ... These results indicate that the X/XO-induced inward current of SG neurons occurs through activation of