Further study showed that AE could suppress the nuclear factor-κB (NF-κB) and phosphorylation of extracellular ... The results of this study suggest that AE directly inhibits TLR4/NF-κB/ERK signaling pathways and decreases ... (IL-6), and monocyte chemoattractant protein-1 (MCP-1) in a dose-dependent manner.
binding sites for NF-κB. ... Also, brazilin suppressed NF-κB activation in TPA-treated MCF-7 cells. ... by brazilin is mediated by the suppression of the NF-κB pathway in MCF-7 cells.
A series of novel diaryl ether analogs possessing gallate moiety were synthesized and NF-κB inhibitory ... NF-κB luciferase activities in prostate LNCaP and colon cancer HCT116 cells showed that 2a, 2c, 2d, 2g ... 충북대학교 동물의학연구소 Journal of Biomedical Research Jae-Kyung Jung, Mi-Sung Lee, Jae-Hwan Kwak, Heesoon Lee
These results indicated that NF-κB p65 can play a role as oncogene in OSCC. ... Immunoreactivity was semi-quantitatively scored and the correlation between the expression of NF-κB p65 ... Hence, the present study analyzed the expression of NF-κB p65 in OSCC from Korean patients.
differentiated from hematopoietic cell lineages of monocyte/macrophages in the presence of receptor activator of NF-xB ... ligand (RANKL) and M-CSF. ... Bok Kwak, Hong-Hee Kim
, and that this increase was blocked by the inhibition of NF-κB acti-vation. ... of β2AR and also that TNFα induces β2AR exp-ression in an NF-κB-dependent manner. ... Chromatin immunoprecipitation and luciferase reporter assay results indicated that NF-κB directly binds
Receptor activator of NF-κB ligand (RANKL) is an essential cytokine for osteoclast differentiation, ... 대한구강생물학회 International Journal of Oral Biology Jeong-Hwa Baek, Sun-Jae Heo, Hyun-Jung Park ... When T cell activation was induced by phorbol 12-myristate 13-acetate (PMA) and ionomycin, RANKL expression
We also found that Fru-Tyr suppressed tumor necrosis factor-alpha (TNF-α)-induced NF-κB transcriptional ... ;2</sub>/M phase cell cycle arrest and apoptotic cell death by modulating of NF-κB. ... (Fru-Tyr), could modulate cell cycle progression and NF-κB activity, and thereby induce apoptotic cell
NF-κB는 I-κB와 결합하면 inactive한 상태로 존재하게 된다. cytokine이 있으면 cytokine이 I-κB를 분해시켜 없애서 NF-κB가 활성화된다. ... NF-κB가 활성화되면 염증반응이 일어나 생존에 관여 하지만, 일부의 경우에는 죽음에 관여하기도 한다. NF-κB는 우리가 아는 거의 모든 pathway에 의해서 활성화된다. ... 인산화된 JAK kinase가 STAT을 F-κB가 자유롭게 되어 활성화된다. 활성화된 NF-κB는 핵 안으로 들어가서 특정 gene을 발현시킨다.
NF-κB는 p50(NFκB1), p52(NFκB2), p65(Rel-A), c-Rel과 Rel-B와 같은 Rel계 homodimer나 heterodimer이다. ... 1)NF-κB signaling 조사 NF-κB는 면역 세포에서 염증 기전에 관여하는 가장 중요한 전사인자 중 하나이다. ... IκB의 인산화와 일련의 분해과정을 통해 핵으로 NF-κB의 전이가 일어난다.
of NF-κ B p65 and degradation of inhibitor of κB-α (IκB-α). ... P. gingivalis-induced activation of nuclear factor-κB (NF-κB) was demonstrated by the results of phosphorylation ... Pharmacological inhibition of each of the three types of MAPKs and NF-κB substantially attenuated P.
protein kinase’s p38, and the signal transduction process of nuclear factor κB (NFκB)-related protein ... This reduction is thought to be due to the inhibition of the signal transduction process of NFκB-related ... Also, baicalin reduced the expression of MMP-8 and MMP-9 in RAW 264.7 cells.
nuclear factor (NF–κb), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-12 (IL-12) and tumor ... B. longum KBB1-26 and BIF-4, B. breve KBB5-22 also showed tolerance to 0.3% of oxgall bile salt. ... B. longum KBB1-26 was survived at pH 2.0.
toll-like receptor 4 and nuclear factor kappa B (NF-κB) induced by LPS. ... Keywords: Actinidia polygama extract (PB203); macrophages; immunomodulator; nuclear factor kappa B (NF-κB ... In addition, PB203-mediated production of NO and TNF-α was attenuated by NF-κB inhibition in RAW264.7
protein kinases and the key transcription factors, AP-1 and NF-κB in LPS-stimulated THP-1 cells. ... Furthermore, the AP-1 DNA binding activity was suppressed by LY30 based upon the dosage, whereas NF-κB ... of IL-1, IL-6, and IL-8.
Soybean sprouts of 47 plants showed the highest NF-κB/AP1 gene expression at the level of 1.13 ± 0.03 ... In addition, NF-kB transcription factor activity and NO production ability were excellent, and it was ... potato, banana, apple, garlic, crown daisy, cabbage and Ailanthus altissima also had high activity of NF-kB
The Toll-like receptor (TLR)2/TLR4 dependency of various LPSs was also determined by measuring NF-κB ... (MCP-1) and tumor necrosis factor-α (TNF-α)-inducing activities were compared in human umbilical vein ... reporter activity in TLR2- or TLR4-expressing 293 cells.
expression of the p65 subunit of NF-κB. ... L-AA effectively inhibited the constitutive nuclear factor-κB (NF-κB) activation and attenuated the nuclear ... -8, and -3 were enhanced by L-AA treatment.
mediators mediated by nuclear factor-kappa B (NF-κB) by inhibition of signal transduction in LPS - induced ... oxide (NO), interleukin-1β (IL-1β), interleukin- 6 (IL-6), TNF-α, inducible nitrous oxide (iNOS) and ... (TNF-α).