Adjuvant Therapy for Breast cancer 유방암 치료
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"Adjuvant Therapy for Breast cancer 유방암 치료"에 대한 내용입니다.목차
1. Radiotherapy2. Targeted therapy
3. Adjuvant Chemotherapy
4. Adjuvant endocrine therapy
본문내용
IntroductionRadiotherapy applies high energy x-rays to destroy cancer cells
Objective of adjuvant radiation therapy
To eradicate any tumor deposits remaining after either breast-conserving surgery or mastectomy.
Reduces risk of locoregional recurrence
Improves breast cancer-specific and overall survival
참고 자료
Antonio et al. “Obesity, Inflammation, and Postmenopausal Breast Cancer: Therapeutic Implications”, October 2011, The Scientific World Journal 11(8):2020-36C K Osborne. et al “Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action”, Br J Cancer. 2004 Mar; 90(Suppl 1): S2–S6.
Dowsett M, Cuzick J, Ingle J, Coates A, Forbes J, Bliss J, Buyse M, Baum M, Buzdar A, Colleoni M, Coombes C, Snowdon C, Gnant M, Jakesz R, Kaufmann M, Boccardo F, Godwin J, Davies C, Peto R. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol. 2010 Jan 20;28(3):509-18. doi: 10.1200/JCO.2009.23.1274. Epub 2009 Nov 30. PMID: 19949017.
Reinbolt RE, Mangini N, Hill JL, Levine LB, Dempsey JL, Singaravelu J, Koehler KA, Talley A, Lustberg MB. Endocrine therapy in breast cancer: the neoadjuvant, adjuvant, and metastatic approach. Semin Oncol Nurs. 2015 May;31(2):146-55. doi: 10.1016/j.soncn.2015.02.002. Epub 2015 Feb 17. PMID: 25951743.
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Sabiston Textbook of Surgery, 21st edition, C. Townsend et al, 2021, pp885-886
NCCN Guidelines version 3.2021 Breast cancer
Harrison 20th edition pp558-565
Meric-Bernstam F, Johnson AM, Dumbrava EEI, et al. Advances in HER2-Targeted Therapy: Novel Agents and Opportunities Beyond Breast and Gastric Cancer. Clin Cancer Res. 2019;25(7):2033-2041.
Synthetic lethality-a new direction in cancer-drug development N Engl J Med. 2009 Jul 9;361(2):189-91. Iglehart JD, Silver DP
Nijman SM. Synthetic lethality: general principles, utility and detection using genetic screens in human cells. FEBS Lett. 2011;585(1):1-6. doi:10.1016/j.febslet.2010.11.024