아토피 가려움증 작용 기전

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Introduction
AD is a chronic relapsing inflammatory skin disease

More than 50% develop asthma
75% develop AR

complex interrelationship of
genetic, environmental, immunologic, and epidermal factors

Epidemiology
Affects 15-30% of children, 2-10% of adult
45% begin within the first 6 mo
60% begin during the first yr
85% begin before 5 yrs

Up to 70%: spontaneous remission before adolescence.

Acute AD
Intensely pruritic, erythematous papule associated with excoriations, vesiculation, and serous exudate
Pathology : spongiosis (intercellular epidermal edema), superficial epidermal hypertrophy and acantholysis

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