원저 : 성인 천식 환자에서 흡연에 따른 폐기능 및 임상적 특성

저작시기 2008.01 |등록일 2010.07.21 파일확장자어도비 PDF (pdf) | 8페이지 | 가격 4,000원
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발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 수록지정보 : 천식 및 알레르기 / 28권 / 4호 / 263 ~ 270 페이지
저자명 : 최종기 ( Jong Ki Choi ) , 강세훈 ( Se Hun Kang ) , 박영훈 ( Young Hoon Park ) , 배윤정 ( Yun Jeong Bae ) , 김태범 ( Tae Bum Kim ) , 이태훈 ( Tae Hoon Lee ) , 박찬선 ( Chan Sun Park ) , 문희범 ( Hee Bom Moon ) , 조상헌 ( Sang Heon Cho ) , 박흥우 ( Heung Woo Park ) , 장윤석 ( Yoon Seok Cha

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Background: Cigarette smoking is common in adult asthmatic patients and the smoking rates in these patients are similar to those in the general population. However, adult asthmatics who are current smokers or ex-smokers have been excluded in many clinical studies. Objective: We investigated the impacts of smoking on pulmonary functions and clinical features of asthmatics by using a data from a recently established adult asthma cohort: COREA (Cohort for Reality and Evolution of Adult Asthma). Method: COREA is a Korean adult asthma cohort established since 2005. 1,283 asthma patients were enrolled in this COREA. The patients in this cohort were divided into 3 groups; the current smoker group, the ex-smoker group and the non-smoker group according to the status of smoking. We analyzed and compared the clinical and laboratory parameters of these 3 groups using clinical data, symptom score, pulmonary functions, and quality of life score. Result: Among 1,283 asthmatic patients, 16% were current smokers, 38% were ex-smokers, and 46% were non-smokers. The current smoker and ex-smoker groups were male dominant. Ex-smokers were older and had a longer history of asthma symptoms, mean treatment duration and smoking. Currently smoking asthmatics coughed more frequently in past 3 months. Current smokers and ex-smokers presented significantly lower FEV1, FVC, FEV1/FVC than nons-mokers (P<0.05). Elevated total serum IgE levels were observed in the current smoking and ex-smoking asthmatics groups. In an induced sputum analysis, eosinophil counts were observed to be reduce in the current smoking asthmatic group. Conclusion: The results of this study indicated that smoking has deteriorating effects on pulmonary functions and clinical respiratory symptoms in asthmatic patients. Education for quitting smoking in asthmatics should be stressed for a better control of asthma. (Korean J Asthma Allergy Clin Immunol 2008;28:263-270)

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