혈청 Gamma-Glutamyltransferase에 따른 복부비만과 제2형 다뇨병간의 관련성: Korean Genome and Epidemiology Study (The Association of Central Obesity with Type 2 Diabetes among Koreans according to the Serum Gamma-Glutamyltransferase Level: Korean Genome and Epidemiology Study)

서지정보

· 발행기관 : 대한예방의학회
· 수록지 정보 : 예방의학회지 / 42권 / 6호 / 386 ~ 391페이지
· 저자명 : 신지연, 정진영, 김성희, 문재동, 노상철, 김영욱, 김양호, 임종한, 주영수, 하은희, 이용환, 이덕희, 김동현, 황준현, 홍영습

초록

Objectives : This cross-sectional study was performed to
examine if the serum gamma-glutamyltransferase (GGT)
level that is within its normal range is associated with the
risk of type 2 diabetes and if the association between the
waist hip ratio (WHR) and type 2 diabetes is different
depending on the serum GGT levels.
Methods : The study subjects were 23,436 persons aged
40 years or older and who participated in regular health
check-ups at 11 hospitals (males: 5,821, females: 17,615).
The gender-specific quintiles of the serum GGT and WHR
were used to examine the associations with type 2
diabetes.
Results : The serum GGT levels within their normal range
were positively associated with type 2 diabetes only in
women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4,
2.1, and 2.5 according to the quintiles of the serum GGT
(ptrend<0.01). The WHR was more strongly associated with
the prevalence of diabetes among the women with a highnormal
serum GGT level as compared with those with a
low-normal serum GGT level (p for interaction=0.02). For
example, the adjusted ORs for women with a low normal
serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according
to the quintiles of the WHR, while those figures were 1.0,
2.4, 3.6, 5.0, and 8.3 among the women with a high normal
serum GGT level. However, in men, the serum GGT was
very weakly associated with type 2 diabetes and the
association between the WHR and type 2 diabetes was not
different depending on the serum GGT level.
Conclusions : Serum GGT within its normal range was
positively associated with type 2 diabetes, and central
obesity was more strongly associated with the prevalence
of type 2 diabetes when the serum GGT level was highnormal.
However, these associations were observed only in
women, which is different from the previous findings. The
stronger relation between central obesity and type 2
diabetes among women with a high-normal serum GGT
level can be useful for selecting a group that is at high risk
for type 2 diabetes irregardless of whatever the underlying
mechanism is.

영어초록

Objectives : This cross-sectional study was performed to
examine if the serum gamma-glutamyltransferase (GGT)
level that is within its normal range is associated with the
risk of type 2 diabetes and if the association between the
waist hip ratio (WHR) and type 2 diabetes is different
depending on the serum GGT levels.
Methods : The study subjects were 23,436 persons aged
40 years or older and who participated in regular health
check-ups at 11 hospitals (males: 5,821, females: 17,615).
The gender-specific quintiles of the serum GGT and WHR
were used to examine the associations with type 2
diabetes.
Results : The serum GGT levels within their normal range
were positively associated with type 2 diabetes only in
women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4,
2.1, and 2.5 according to the quintiles of the serum GGT
(ptrend<0.01). The WHR was more strongly associated with
the prevalence of diabetes among the women with a highnormal
serum GGT level as compared with those with a
low-normal serum GGT level (p for interaction=0.02). For
example, the adjusted ORs for women with a low normal
serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according
to the quintiles of the WHR, while those figures were 1.0,
2.4, 3.6, 5.0, and 8.3 among the women with a high normal
serum GGT level. However, in men, the serum GGT was
very weakly associated with type 2 diabetes and the
association between the WHR and type 2 diabetes was not
different depending on the serum GGT level.
Conclusions : Serum GGT within its normal range was
positively associated with type 2 diabetes, and central
obesity was more strongly associated with the prevalence
of type 2 diabetes when the serum GGT level was highnormal.
However, these associations were observed only in
women, which is different from the previous findings. The
stronger relation between central obesity and type 2
diabetes among women with a high-normal serum GGT
level can be useful for selecting a group that is at high risk
for type 2 diabetes irregardless of whatever the underlying
mechanism is.

참고자료

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