ㆍ발행기관 : 대한인수공통전염병학회ㆍ수록지정보 : 대한인수공통전염병학회 학술발표초록집 / 2019권 / 1호 ㆍ저자명 : ( Gi Yong Lee ) , ( Kun Taek Park ) , ( Yong Ho Park ) , ( Soo-jin Yang )
Introduction Sequence type (ST) 398 methicillin-resistant Staphylococcus aureus (MRSA) has been reported as a dominant clonal lineage in livestock animals, especially in pigs. Recently, increased number of human infections with ST398 MRSA have been reported worldwide, indicating high zoonotic potentials of this pathogen.Materials and methods In this study, using two ST398 MRSA strains each isolated from a pig and a pig farm worker in Korea, we investigated: i) antimicrobial resistance profiles , ii) genotypes associated with virulence and antimicrobial resistance, iii) comparative genome analysis using whole genome sequence data.Results Both ST398 MRSA isolates harbored SCCmec V for methicillin resistance and exhibited identical multidrug resistance phenotype with a number of antimicrobial resistance genes. However, comparative and functional genome analyses revealed that the two MRSA strains had differences in genome size and numbers of coding sequences (CDSs). These differences suggested that the ST398 MRSA strains may have evolved rapidly in response to different host adaptations.Conclusions Detailed genome analyses of the two ST398 MRSA strains revealed that the genetic relatedness of the two strains was close to European sub-lineages. Further, the differences observed in comparative WGS analyses warrants future research in defining host-specific adaptation of ST398 MRSA during animal-to-human or human-to-animal transmission.