P534 : Actinic cheilitis treated with topical ingenol mebutate gel (Picato®) 0.015%: A case report
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ㆍ발행기관 : 대한피부과학회ㆍ수록지정보 : 프로그램북(구 초록집) / 68권 / 1호 ㆍ저자명 : ( Jong Sic Kim ) , ( Hwa Young Jung ) , ( Yuri Woo ) , ( Miri Kim ) , ( Hyun Jeong Park )
Actinic cheilitis is a common, premalignant lesion often affecting the lower lip that requires early and effective treatment. There are several treatment options including surgical excision, cryotherapy, carbon dioxide laser, and topical agents such as 5-fluorouracil or 5% imiquimod. A 79-year-old woman presented with a painful patch on her lower lip for 1 month duration. On physical examination, erythematous keratotic patches on the lower lip were shown. Histopathological findings revealed parakeratosis and atypical keratinocytes in the epidermis with marked solar elastosis in the dermis. The patient was diagnosed as actinic cheilitis. We applied topical ingenol mebutate gel (Picato, Leo Pharma, Inc.) 0.015% for the three consecutive days. After treatment with ingenol mebutate gel (Picato®), the patient experienced painful erythematous scaly patches and erosion at day 1. Despite daily wet dressing, the local treatment site reaction persisted for two months. Ingenol mebutate gel (Picato®) has proven to be effective for the field treatment of actinic keratosis. Contrary to our case, in a report of four caucasian actinic cheilitis patients treated with ingenol mebutate gel (Picato®) 0.015%, three patients showed minimal local reaction. Some differences regarding drug action and efficacy may exist between Caucasian and Asian patients, but more studies and long-term follow-up are necessary.