P532 : Biodegradable microneedle patch to increase the penetration of topical steroid in the prurigo nodularis
저작시기 2016.01|등록일 2016.05.17어도비 PDF (pdf)|2페이지|가격 1,000원
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ㆍ발행기관 : 대한피부과학회ㆍ수록지정보 : 프로그램북(구 초록집) / 68권 / 1호 ㆍ저자명 : ( Jung U Shin ) , ( Hong Kyu Kang ) , ( Howard Chu ) , ( Jungsoo Lee ) , ( Hemin Lee ) , ( Ju Hee Lee ) , ( Kwang Hoon Lee )
Although topical steroid is the first choice of drug in many skin diseases, some patients, such as prurigo nodularis (PN) patients, do not sufficiently respond to strong steroids, possibly due to low penetration rate of drugs in thickened skin. This study was performed to investigate if applying biodegradable microneedle (MN) patch after topical steroid increases the penetration of topical steroids and treatment efficacy in PN patients. The penetration rate was measured by Franz diffusion cell system using 3D skin. Patients who have bilateral symmetrical PN lesions were included. Both right and left sides were treated with topical steroid twice a day and only right side was applied with biodegradable MN patch after topical steroid once a week. The penetration of topical steroid was significantly higher in biodegradable MN applied 3D skin equivalent than non-applied 3D skin equivalent. Area and height of PN decreased after 4 weeks of treatment in both sides; however, biodegradable MN patch applied side showed more decrease in area and height of PN compared to non-applied side (p < 0.05). Visual analog scale was also significantly lower in biodegradable MN applied side (p < 0.05). Our results demonstrated that applying biodegradable MN patch after the use of topical steroid can enhance the penetration of topical steroid and increase the treatment efficacy. Therefore we suggest that this novel patch can be used efficiently in PN treatment.