Poster Session : PS 1003 ; Lactulose Breath Test as Prognostic Factor in Irritable Bowel Syndrome

저작시기 2014.01 |등록일 2015.01.05 | 최종수정일 2015.04.23 파일확장자어도비 PDF (pdf) | 1페이지 | 가격 1,000원
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발행기관 : 대한내과학회 수록지정보 : 대한내과학회 추계학술발표논문집 / 2014권 / 1호
저자명 : ( Eunae Cho ) , ( Jong Sun Rew ) , ( Hyun Soo Kim ) , ( Chang Hwan Park ) , ( Seon Young Park ) , ( Sung Kyu Choi )

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Background: Traditional symptom-based therapies of irritable bowel syndrome (IBS) are directed at the relief of individual IBS symptoms. However, prognostic factors for responses to these treatments have not yet been well studied. The purpose of this study was to evaluate predictors for treatment response in patients with IBS. Methods: A total of 183 patients diagnosed with IBS according to Rome III criteria and underwent lactulose breath test (LBT) from October 2010 to June 2014 were reviewed retrospectively. All participants had checked global IBS symptom questionnaire on the day of the LBT. Overall improvement of global IBS symptoms was reassessed after 4 weeks of treatment. Results: Sixty-one subjects (33.3%) were classified as diarrhea-predominant IBS (IBS-D), 38 (20.8%) as constipation-predominant IBS (IBS-C), 17 (9.3%) as mixed-symptoms IBS (IBS-M), and 67 (36.6%) as unspecifi ed type IBS (IBS-U). LBT results were not signifi cantly different in relation to IBS subtypes. One hundred and nineteen patients (65%) had positive LBT, while 64 patients (35%) had negative LBT. Among the 119 patients with positive LBT, overall symptom improvement was observed in 91 patients (76.5%). Subjects with underlying psychological problems were less likely to have symptom improvement (4/28 vs. 3/91 p=0.031). High basal hydrogen level (>20 ppm) was more frequent in the subjects without symptom improvement (6/28 vs. 6/91, p=0.023). However, underlying psychological problems and high basal hydrogen level were not signifi cantly associated with poor treatment response in patients with negative LBT. Conclusions: High basal hydrogen production correlates with poor treatment response in patients with IBS and positive LBT. This result suggests that LBT can be used as a tool for prediction of treatment response in patients with IBS and positive LBT.

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Poster Session : PS 1003 ; Lactulose Breath Test as Prognostic Factor in Irritable Bowel Syndrome
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