[정신과]항정신병 약물

소개글

항정신병 약물입니다.

목차

⊙ Development of Antipsychotics
⊙ Pharmacodynamics
⊙ Side effect
⊙ Atypical antipsychotics
⊙ Reference

본문내용

⊙ Classification
Ⅰ. Typical antipsychotics ( Conventional antipsychotics )
Phenothiazines - Aliphatic 군 : chlorpromazine ( Low potency drug )
Piperidine 군 : thioridazine ( Low potency drug )
Piperazine 군 : perphenazine, trifluoperazine ( High )
Butyrophenones : haloperidol ( High potency drug )
Thioxanthenes

Ⅱ. Atypical antipsychotics
: Clozapine, Risperidone, Olanzapine, Quetiapine, Ziprasidone


⊙ Pharmacodynamics

※ Dopamine pathway
1) Nigrostriatal pathway : Dopamine action 감소 ---> EPS, Tardive dyskinesia
2) Tubuloinfundibular pathway : Dopamine action 감소 ---> Hyperprolactinemia
3) Mesolimbic pathway : Dopamine action 감소 ---> Positive symptoms ↓
4) Mesocortical pathway : Dopamine action 증가 ---> Negative symptoms ↓
Ⅰ. Dopamine receptor antagonist
: Typical antipsychotics
⇒ Blockade of dopamine 2 receptor
: 4개의 모든 dopamine pathway에서
D2 receptor 를 block 함.
① Nigrostriatal pathway
: Dopamine action 감소 ---> EPS, Tardive dyskinesia
② Tubuloinfundibular pathway
: Dopamine action 감소 ---> Hyperprolactinemia
③ Mesolimbic pathway

참고 자료

1. Essential psychopharmacology ( Neuroscientific basis & Practical applications )
2nd edit., 2000, Stephen M. Stahl , Cambridge university press, p.401~436
2. Synopsis of psychiatry ( Behavioral science/ Clinical psychiatry ) 9th edit., 2003
Benjamin James Sadock & Virginia Alcott Sadock, Kaplan & Sadock, p.1104~1113
3. Principles and practice of psychopharmacotherapy , 3rd edit., 2001
Philip G. Janicak etc. Lippincott Williams & Wilkins, p.73~178
4. 최신정신의학, 4th edit., 1999, 민성길 외, 일조각, p.651~659