Erythropoietin, Historical Review
- 최초 등록일
- 2013.10.25
- 최종 저작일
- 2011.12
- 17페이지/ MS 파워포인트
- 가격 1,000원
목차
0. Plans of Endocrinology Project on EPO
1. Why EPO, Importance of Erythropoietin
2. Major History of EPO
3. Erythropoietin Receptor
본문내용
Binding of Epo to EpoR
Conformational change ; tight connection of the two monomeric EpoR molecules
Two JAK2 activated
Tyrosine residues of the EpoR are phosphorylated to provide docking sites for signaling proteins containing SRC homology 2 (SH2) domains
Induce Epo signals;
PI-3K/Akt, STAT5, MAP kinase
참고 자료
http://en.wikipedia.org/wiki/Erythropoietin
http://genome.ucsc.edu/cgibin/hgTracks org=Humandb=hg19position=chr7:100318423100321323
「Erythropoietin after a century of research: younger than ever.」 / Jelkmann W. / Eur J Haematol. 2007 Mar;78(3):183205. Epub 2007 Jan 23. Review. / PMID: 17253966 [PubMed indexed for MEDLINE
Blood. 1993 Feb 1;81(3):61723. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Fandrey J, Bunn HF. Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA.