TAK1 ppt
- 최초 등록일
- 2012.04.24
- 최종 저작일
- 2011.01
- 12페이지/ MS 파워포인트
- 가격 1,000원
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본문내용
Four splicing variants of TAK1 have been described. Publications dealing with the function of TAK1 dexcribe almost exclusively the properties of the long splicing vaiants A and B. B differs from A by a deletion of 28 amino acids due to alternative splicing variants C and D lack 99 amino acids of the C-terminal sequence because a frame shift caused by alternative slicing of exon 16 leads to truncation of the protein.
Most importantly, the deleted C-terminal sequence in splice variants C and D has been demonstrated to be required for the activation of kinase through upstream signaling molecules like TAB2 or TAB3.
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