한국인 구강편평상피세포암종 환자에서 CXCL1과 CXCL2 유전자의 다형성에 관한 연구

서지정보

ㆍ발행기관 : 대한구강악안면병리학회 ㆍ수록지정보 : 대한구강악안면병리학회지 / 35권 / 3호
ㆍ저자명 : 강상욱, 김준열, 조재오

목차

Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
1. Study participants
2. SNP Selection and genotyping
3. Histological examination
4. Statistical analysis
Ⅲ. RESULTS
1. Clinical and histological characteristics ofpatients with OSCC
2. Allelic association and CXCL1 and CXCL2haplotypes in patients and controls
3. Alteration of transcription factor by CXCL1-442C/T and CXCL2 -264T/C single nucleotidepolymorphism
4. CXCL1 -442C/T and CXCL2 -264T/C singlenucleotide polymorphism in patients andcontrols
5. CXCL1 -442C/T and CXCL2 -264T/C singlenucleotide polymorphism and nuclearaberration in OSCC patients
Ⅳ. DISCUSSION
Ⅴ. REFERENCES

영어 초록

Oral squamous cell carcinoma (OSCC) is the most common cancer of oral cancers. Recent data suggest that chemokines could be essential players in carcinogenesis and that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. The aim of this study was to test the hypothesis that expression of SNPs in chemokine, CXCL1 and CXCL2 correlates with oral squamous cell carcinomas in Korean population. The CXCL1 and CXCL2 genotypes were determined in 21 subjects with oral squamous cell carcinoma and 90 control subjects without oral squamous cell carcinoma. The genotypes were determined by direct sequencing. The genotype distribution and allele frequency within the OSCC patients were not significantly different from those of control subjects. But among OSCC subjects, there was significant difference of CXCL1 gene in the degree of nuclear aberration. These findings suggest that CXCL1 -442C/T polymorphism and CXCL2 -264T/C polymorphism are not related to the development of OSCC but polymorphism of CXCL1 gene might have a relation with progression of OSCC in Korean population.

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