[동물생리학] inhibition zone assay

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Antimicrobial peptides originating from multicellular organisms have been discovered, mainly in arthropods including insects, vertebrates, and plants (1). Interestingly, some antimicrobial peptides isolated from evolutionally distant origins are structurally similar. For example, defensins were originally found in mammalian neutrophil cells (2). Insect/arthropod defensins, isolated from the body fluid of insects and other arthropods, show a certain degree of sequence similarity with mammalian defensins (3). Both mammalian and insect defensins contain six cysteine residues contributing intramolecular disulfide bridges.

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