Antitumor agents from microorganism

목차

1.Antitumor Agents Introduction
2.Antitumor agents
3.Screening systems used to search for antitumor compounds of 4.microbial origin using tumor cells
5.Screening systems used to search for antitumor compounds of 6.microbial origin using bacteria
7.Screening Methods – Animal tumor systems
8.Screening Methods – Autochthonous tumors(자발생 종양)
9.Screening Methods – Cell culture systems
10.Screening Methods – Bacterial systems
11.Antitumor drugs
12.Conclusion remarks

본문내용

Antitumor Agents Introduction
Until now many antitumor substances have been discovered, including synthetic substances, natural products of higher plant origin, and antitumor antibiotics. These antitumor antibiotics have played an important role in the development of antitumor angents.
Although actinomycin D, mitomycin C, doxorubicin, bleomycin, etc., have been discovered and are used clinically, these antibiotics possess undesirable side effects. Thus, novel antitumor antibiotics possessing a more specific activity or a new type of structure are always being looked for. Antimicrobial agents can discriminate between mammalian cells and bacteria while antitumor agents can only identify and differentiate tumor cells from normal cells on the basis of the rapidly dividing nature of tumor cells.

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