골수부전증후군
- 최초 등록일
- 2013.08.06
- 최종 저작일
- 2013.07
- 4페이지/ 한컴오피스
- 가격 1,000원
목차
1. Definition
2. Epidemiology
3.Classification
4. Etiology
5. Pathogenesis
6. Cytogenetic abnormalities
7. Clinical features
8. Physical examination
9. Laboratory Studies
10. Diffential diagnosis
11. Prognosis
12. Treatment
본문내용
1. Definition
Heterogeneous group of hematologic disorders
Cytopenia associated dysmorphic(abnormal appearing), cellular marrow.
Ineffective blood cell production.
2. Epidemiology
Disease of the older adult
-80% of patients are >60
-mean age at onset >70 yr
Prevalence
-<15 yr : 0.3/100,000
-50-70 yr : 4/100,000
->79 yr : 30/100,000
Secondary MDS
-나이와 상관없이 항암 치료 후 시간이 지날수록 발생이 증가
-Poor Prognosis
<중 략>
6. Cytogenetic abnormalities
Half of patients
Aneuploidy > translocation
Loss of all or part of 5, 7, 20, trisomy 8
11q23 following topo-2 inhibitor
Type & number of cytogenetic abnormality strongly correlate with the probability of leukemic transformation & survival
참고 자료
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