Cullin 4B Is Recruited to Tristetraprolin-Containing Messenger Ribonucleoproteins and
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- 2012.04.24
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- 2011.01
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Posttranscriptional regulation of TNF-a
One of the best-studied cis-elements is the AU-rich element (ARE).
Ex) TNF-a 3’ UTR ARE를 deletion 시킨 germline mice의 macrophage와 T cell에서 TNF-a protein 양이 3~10배 더 높았다. Kontoyiannis at.el. Immunity 10:387-398
Gene expression regulation
In eukaryotes, regulation of gene expression occurs at several levels
Chromatin structure plays an important role in whether a gene is active or inactive
Regulation of transcription initiation involves a gene’s promoter and regulatory sites
Methylation of DNA can control gene transcription
Three main areas of eukaryotic regulation of gene expression
Transcriptional
posttranscriptional
Posttranslational
Posttranscriptional regulation controls availability of mRNA to ribosomes
Masking proteins bind to mRNA to prevent translation
Signal for mRNA activation removes masking proteins during development
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